Epub 2018 Jun 11. Virulence. The adhesin PspC from Streptococcus pneumoniae is a choline-binding protein that is …
Lactococcus lactis subsp. L. lactis subsp. Expert Rev Vaccines. Epub 2005 Oct 13. Old synonyms: Streptococcus lactis (Lister 1873) Lohnis 1909, Streptococcus lactis subsp. SDS-PAGE analysis of heterologous M…, Figure 1. Figure 1. Binsker U, Kohler TP, Krauel K, Kohler S, Schwertz H, Hammerschmidt S. J Biol Chem. Phylogenetic analysis based on 16S rDNA gene sequence comparison indicated similarity among the L. lactis isolates as well as between the isolates and reference sequences. SDS-PAGE analysis of heterologous M protein expression, Figure 2. Get the latest public health information from CDC: https://www.coronavirus.gov.  | 
We use cookies to help provide and enhance our service and tailor content and ads. 2014 Sep;21(9):1343-9. doi: 10.1128/CVI.00330-14. This site needs JavaScript to work properly. 2015;14(11):1459-70. doi: 10.1586/14760584.2015.1081817. Expert Rev Vaccines. Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci. Lactococcus lactis is a non-pathogenic bacterium that is used in the food industry but is also used as a heterologous host to reveal protein functions of pathogenic bacteria. After intranasal challenge with M28 streptococci, survival of M×10-immunized mice was significantly higher than that of unimmunized mice. 2015 Jun 5;290(23):14542-55. doi: 10.1074/jbc.M114.623876. The isolates were identified as L. lactis (27 isolates) and L. garvieae (1 isolate). Further studies should be conducted to understand the importance of Lactococcus, especially L. lactis, as pathogenic microbes in veterinary medicine and food safety. The authors declare No Conflict of Interest. Clipboard, Search History, and several other advanced features are temporarily unavailable. The N-terminal fragment of streptococcal M protein elicits protective antibodies and is an attractive vaccine target. The results demonstrated that PspC is sufficient for adhesion and subsequent invasion of host epithelial cells expressing the human polymeric Ig receptor (hpIgR). 2018 Jun;62(6):395-404. doi: 10.1111/1348-0421.12595. 4. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. In this study, we investigated an outbreak of bovine mastitis thought to be associated with Lactococcus bacteria by using microbiological and molecular techniques. 1. Group A Streptococcus; M protein; intranasal vaccine; live bacterial vaccine.

 |  Epub 2014 Mar 26. A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci. Molecular basis of host specificity in human pathogenic bacteria. Clipboard, Search History, and several other advanced features are temporarily unavailable. However, studies have also linked Lactococcus bacteria to infection. The adhesin PspC from Streptococcus pneumoniae is a choline-binding protein that is non-covalently anchored to the bacterial cell wall. For example, certain variants of Lactococcus species have been associated with bovine mastitis (e.g., Lactococcus lactis and Lactococcus garvieae).

However, studies have also linked Lactococcus bacteria to infection. Wozniak A, García P, Geoffroy EA, Aguirre DB, González SA, Sarno VA, Dale JB, Salazar-Echegarai FJ, Vera A, Bueno SM, Kalergis AM. 2004 Feb;3(1):43-58. doi: 10.1586/14760584.3.1.43. In this study, an intranasal live bacterial vaccine comprising 10 strains of Lactococcus lactis, each expressing one N-terminal fragment of M protein, has been developed.

Clin Vaccine Immunol. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. In conclusion, expression of the chimeric PspC confers adhesive properties to L. lactis and indicates the potential of L. lactis as a suitable host to study the impact of individual bacterial factors on their capacity to interfere with the host and manipulate eukaryotic epithelial cells. 2007 May 1;178(9):5848-58. doi: 10.4049/jimmunol.178.9.5848. 2018 Mar 13;9(2):e00264-18. Immunogenicity of vaccine strains evaluated…, Figure 2. To assess the exclusive impact of pneumococcal surface protein C (PspC) on the interplay with its host we generated recombinant L. lactis producing a nisin-inducible and covalently anchored variant of PspC on the lactococcal cell surface. USA.gov.

Keywords: Live bacterial-vectored vaccines cost less to manufacture because the processes involved are less complex than those required for production of protein subunit vaccines. Streptococcus pyogenes (group A Streptococcus) causes diseases ranging from mild pharyngitis to severe invasive infections. In contrast, when mice were challenged with M75 streptococci, survival of M×10-immunized mice did not differ significantly from that of unimmunized mice. Mucosal vaccine made from live, recombinant Lactococcus lactis protects mice against pharyngeal infection with Streptococcus pyogenes. Lactococcus lactis is a non-pathogenic bacterium that is used in the food industry but is also used as a heterologous host to reveal protein functions of pathogenic bacteria.

Georgieva M, Kagedan L, Lu YJ, Thompson CM, Lipsitch M. mBio. We used bacterial isolation, next-generation sequencing, DNA fingerprinting, and other methods to test our hypothesis that Lactococcus microbes were the primary pathogen causing the mastitis outbreak.

Epub 2014 Jul 23. Lipid core peptide technology and group A streptococcal vaccine delivery. Emerg Microbes Infect. This site needs JavaScript to work properly.

Good MF, Pandey M, Batzloff MR, Tyrrell GJ. In summary, our findings suggest that Lactococcus bacteria are a potential etiological agent in the mastitis outbreak studied. Get the latest public health information from CDC: https://www.coronavirus.gov. Please enable it to take advantage of the complete set of features! HHS Get the latest research from NIH: https://www.nih.gov/coronavirus. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.

Epub 2015 Apr 20. By continuing you agree to the use of cookies.  |  Appl Microbiol Biotechnol.

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